Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations
Identifieur interne : 001415 ( Main/Corpus ); précédent : 001414; suivant : 001416Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations
Auteurs : Nadège Limousin ; Eric Konofal ; Elias Karroum ; Ebba Lohmann ; Ioannis Theodorou ; Alexandra Dürr ; Isabelle ArnulfSource :
- Movement Disorders [ 0885-3185 ] ; 2009-10-15.
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Abstract
Parkin gene mutations cause a juvenile parkinsonism. Patients with these mutations may commonly exhibit REM sleep behaviour disorders, but other sleep problems (insomnia, sleepiness, restless legs syndrome) have not been studied. The aim of this study was to evaluate the sleep‐wake phenotype in patients with two parkin mutations, compared with patients with idiopathic Parkinson's disease (iPD). Sleep interview and overnight video‐polysomnography, followed by multiple sleep latency tests, were assessed in 11 consecutive patients with two parkin mutations (aged 35–60 years, from seven families) and 11 sex‐matched patients with iPD (aged 51–65 years). Sleep complaints in the parkin group included insomnia (73% patients versus 45% in the iPD group), restless legs syndrome (45%, versus none in the iPD group, P = 0.04), and daytime sleepiness (45%, versus 54% in the iPD group). Of the parkin patients, 45% had REM sleep without atonia, but only 9% had a definite REM sleep behavior disorder. All sleep measures were similar in the parkin and iPD groups. Two parkin siblings had a central hypersomnia, characterized by mean daytime sleep latencies of 3 min, no sleep onset REM periods, and normal nighttime sleep. Although the patients with two parkin mutations were young, their sleep phenotype paralleled the clinical and polygraphic sleep recording abnormalities reported in iPD, except that restless legs syndrome was more prevalent and secondary narcolepsy was absent. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.22711
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last="Dürr">Alexandra Dürr</name><affiliation><mods:affiliation>INSERM UMR S679, Neurologie et Thérapeutique Expérimentale, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Département de Génétique et Cytogénétique, Hôpital Pitié‐Salpêtrière, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name><affiliation><mods:affiliation>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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Patients with these mutations may commonly exhibit REM sleep behaviour disorders, but other sleep problems (insomnia, sleepiness, restless legs syndrome) have not been studied. The aim of this study was to evaluate the sleep‐wake phenotype in patients with two parkin mutations, compared with patients with idiopathic Parkinson's disease (iPD). Sleep interview and overnight video‐polysomnography, followed by multiple sleep latency tests, were assessed in 11 consecutive patients with two parkin mutations (aged 35–60 years, from seven families) and 11 sex‐matched patients with iPD (aged 51–65 years). Sleep complaints in the parkin group included insomnia (73% patients versus 45% in the iPD group), restless legs syndrome (45%, versus none in the iPD group, P = 0.04), and daytime sleepiness (45%, versus 54% in the iPD group). Of the parkin patients, 45% had REM sleep without atonia, but only 9% had a definite REM sleep behavior disorder. All sleep measures were similar in the parkin and iPD groups. Two parkin siblings had a central hypersomnia, characterized by mean daytime sleep latencies of 3 min, no sleep onset REM periods, and normal nighttime sleep. Although the patients with two parkin mutations were young, their sleep phenotype paralleled the clinical and polygraphic sleep recording abnormalities reported in iPD, except that restless legs syndrome was more prevalent and secondary narcolepsy was absent. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Nadège Limousin MD</name><affiliations><json:string>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</json:string></affiliations></json:item><json:item><name>Eric Konofal MD, PhD</name><affiliations><json:string>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</json:string></affiliations></json:item><json:item><name>Elias Karroum MD</name><affiliations><json:string>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</json:string></affiliations></json:item><json:item><name>Ebba Lohmann MD</name><affiliations><json:string>INSERM UMR S679, Neurologie et Thérapeutique Expérimentale, Paris, France</json:string></affiliations></json:item><json:item><name>Ioannis Theodorou MD, PhD</name><affiliations><json:string>Laboratoire d'Immunologie cellulaire et tissulaire, Hôpital Pitié‐Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Alexandra Dürr MD, PhD</name><affiliations><json:string>INSERM UMR S679, Neurologie et Thérapeutique Expérimentale, Paris, France</json:string><json:string>Département de Génétique et Cytogénétique, Hôpital Pitié‐Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Isabelle Arnulf MD, PhD</name><affiliations><json:string>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hypersomnia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>restless legs syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>inborn genetic diseases</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>REM sleep behavior disorder</value></json:item></subject><articleId><json:string>MDS22711</json:string></articleId><language><json:string>eng</json:string></language><abstract>Parkin gene mutations cause a juvenile parkinsonism. Patients with these mutations may commonly exhibit REM sleep behaviour disorders, but other sleep problems (insomnia, sleepiness, restless legs syndrome) have not been studied. The aim of this study was to evaluate the sleep‐wake phenotype in patients with two parkin mutations, compared with patients with idiopathic Parkinson's disease (iPD). Sleep interview and overnight video‐polysomnography, followed by multiple sleep latency tests, were assessed in 11 consecutive patients with two parkin mutations (aged 35–60 years, from seven families) and 11 sex‐matched patients with iPD (aged 51–65 years). Sleep complaints in the parkin group included insomnia (73% patients versus 45% in the iPD group), restless legs syndrome (45%, versus none in the iPD group, P = 0.04), and daytime sleepiness (45%, versus 54% in the iPD group). Of the parkin patients, 45% had REM sleep without atonia, but only 9% had a definite REM sleep behavior disorder. All sleep measures were similar in the parkin and iPD groups. Two parkin siblings had a central hypersomnia, characterized by mean daytime sleep latencies of 3 min, no sleep onset REM periods, and normal nighttime sleep. Although the patients with two parkin mutations were young, their sleep phenotype paralleled the clinical and polygraphic sleep recording abnormalities reported in iPD, except that restless legs syndrome was more prevalent and secondary narcolepsy was absent. © 2007 Movement Disorder Society</abstract><qualityIndicators><score>6.979</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1512</abstractCharCount><pdfWordCount>4243</pdfWordCount><pdfCharCount>27173</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>228</abstractWordCount></qualityIndicators><title>Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations</title><genre><json:string>article</json:string></genre><host><volume>24</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>7</total><last>1976</last><first>1970</first></pages><issn><json:string>0885-3185</json:string></issn><issue>13</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22711</json:string></doi><id>3AEDA0D9D64673FD2CEBE7DA12590A03F11454B6</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/3AEDA0D9D64673FD2CEBE7DA12590A03F11454B6/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/3AEDA0D9D64673FD2CEBE7DA12590A03F11454B6/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/3AEDA0D9D64673FD2CEBE7DA12590A03F11454B6/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: All authors report no financial disclosure related to the research covered in the article. This was not an industry‐supported study.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations</title><author><persName><forename type="first">Nadège</forename><surname>Limousin</surname></persName><roleName type="degree">MD</roleName><affiliation>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</affiliation></author><author><persName><forename type="first">Eric</forename><surname>Konofal</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</affiliation></author><author><persName><forename type="first">Elias</forename><surname>Karroum</surname></persName><roleName type="degree">MD</roleName><affiliation>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</affiliation></author><author><persName><forename type="first">Ebba</forename><surname>Lohmann</surname></persName><roleName type="degree">MD</roleName><affiliation>INSERM UMR S679, Neurologie et Thérapeutique Expérimentale, Paris, France</affiliation></author><author><persName><forename type="first">Ioannis</forename><surname>Theodorou</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Laboratoire d'Immunologie cellulaire et tissulaire, Hôpital Pitié‐Salpêtrière, Paris, France</affiliation></author><author><persName><forename type="first">Alexandra</forename><surname>Dürr</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>INSERM UMR S679, Neurologie et Thérapeutique Expérimentale, Paris, France</affiliation><affiliation>Département de Génétique et Cytogénétique, Hôpital Pitié‐Salpêtrière, Paris, France</affiliation></author><author><persName><forename type="first">Isabelle</forename><surname>Arnulf</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: Unité des Pathologies du Sommeil, Hôpital Pitié‐Salpêtrière, 47‐83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France</p></note><affiliation>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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Patients with these mutations may commonly exhibit REM sleep behaviour disorders, but other sleep problems (insomnia, sleepiness, restless legs syndrome) have not been studied. The aim of this study was to evaluate the sleep‐wake phenotype in patients with two parkin mutations, compared with patients with idiopathic Parkinson's disease (iPD). Sleep interview and overnight video‐polysomnography, followed by multiple sleep latency tests, were assessed in 11 consecutive patients with two parkin mutations (aged 35–60 years, from seven families) and 11 sex‐matched patients with iPD (aged 51–65 years). Sleep complaints in the parkin group included insomnia (73% patients versus 45% in the iPD group), restless legs syndrome (45%, versus none in the iPD group, P = 0.04), and daytime sleepiness (45%, versus 54% in the iPD group). Of the parkin patients, 45% had REM sleep without atonia, but only 9% had a definite REM sleep behavior disorder. All sleep measures were similar in the parkin and iPD groups. Two parkin siblings had a central hypersomnia, characterized by mean daytime sleep latencies of 3 min, no sleep onset REM periods, and normal nighttime sleep. Although the patients with two parkin mutations were young, their sleep phenotype paralleled the clinical and polygraphic sleep recording abnormalities reported in iPD, except that restless legs syndrome was more prevalent and secondary narcolepsy was absent. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>hypersomnia</term></item><item><term>restless legs syndrome</term></item><item><term>inborn genetic diseases</term></item><item><term>REM sleep behavior disorder</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-01-20">Received</change><change when="2009-07-05">Registration</change><change when="2009-10-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3AEDA0D9D64673FD2CEBE7DA12590A03F11454B6/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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href="file:MDS.MDS22711.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="42"></count><count type="wordTotal" number="5738"></count></countGroup><titleGroup><title type="main" xml:lang="en">Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two <i>parkin</i> mutations<link href="#fn1"></link></title><title type="short" xml:lang="en">Sleep in Parkin Mutations</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Nadège</givenNames><familyName>Limousin</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Eric</givenNames><familyName>Konofal</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Elias</givenNames><familyName>Karroum</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Ebba</givenNames><familyName>Lohmann</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Ioannis</givenNames><familyName>Theodorou</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2 #af4"><personName><givenNames>Alexandra</givenNames><familyName>Dürr</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Isabelle</givenNames><familyName>Arnulf</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>isabelle.arnulf@psl.aphp.fr</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>INSERM UMR S679, Neurologie et Thérapeutique Expérimentale, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Laboratoire d'Immunologie cellulaire et tissulaire, Hôpital Pitié‐Salpêtrière, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="FR" type="organization"><unparsedAffiliation>Département de Génétique et Cytogénétique, Hôpital Pitié‐Salpêtrière, Paris, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">hypersomnia</keyword><keyword xml:id="kwd3">restless legs syndrome</keyword><keyword xml:id="kwd4">inborn genetic diseases</keyword><keyword xml:id="kwd5">REM sleep behavior disorder</keyword></keywordGroup><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22711:MDS_22711_sm_supptable1"></mediaResource><caption>Supporting Information Table E1.</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22711:MDS_22711_sm_supptable2"></mediaResource><caption>Supporting Information Table E2.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><i>Parkin</i> gene mutations cause a juvenile parkinsonism. Patients with these mutations may commonly exhibit REM sleep behaviour disorders, but other sleep problems (insomnia, sleepiness, restless legs syndrome) have not been studied. The aim of this study was to evaluate the sleep‐wake phenotype in patients with two <i>parkin</i> mutations, compared with patients with idiopathic Parkinson's disease (iPD). Sleep interview and overnight video‐polysomnography, followed by multiple sleep latency tests, were assessed in 11 consecutive patients with two <i>parkin</i> mutations (aged 35–60 years, from seven families) and 11 sex‐matched patients with iPD (aged 51–65 years). Sleep complaints in the <i>parkin</i> group included insomnia (73% patients versus 45% in the iPD group), restless legs syndrome (45%, versus none in the iPD group, <i>P</i> = 0.04), and daytime sleepiness (45%, versus 54% in the iPD group). Of the <i>parkin</i> patients, 45% had REM sleep without atonia, but only 9% had a definite REM sleep behavior disorder. All sleep measures were similar in the <i>parkin</i> and iPD groups. Two <i>parkin</i> siblings had a central hypersomnia, characterized by mean daytime sleep latencies of 3 min, no sleep onset REM periods, and normal nighttime sleep. Although the patients with two <i>parkin</i> mutations were young, their sleep phenotype paralleled the clinical and polygraphic sleep recording abnormalities reported in iPD, except that restless legs syndrome was more prevalent and secondary narcolepsy was absent. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: All authors report no financial disclosure related to the research covered in the article. This was not an industry‐supported study.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Sleep in Parkin Mutations</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two</title></titleInfo><name type="personal"><namePart type="given">Nadège</namePart><namePart type="family">Limousin</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eric</namePart><namePart type="family">Konofal</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elias</namePart><namePart type="family">Karroum</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ebba</namePart><namePart type="family">Lohmann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>INSERM UMR S679, Neurologie et Thérapeutique Expérimentale, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ioannis</namePart><namePart type="family">Theodorou</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Laboratoire d'Immunologie cellulaire et tissulaire, Hôpital Pitié‐Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexandra</namePart><namePart type="family">Dürr</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>INSERM UMR S679, Neurologie et Thérapeutique Expérimentale, Paris, France</affiliation><affiliation>Département de Génétique et Cytogénétique, Hôpital Pitié‐Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Isabelle</namePart><namePart type="family">Arnulf</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Unité des Pathologies du sommeil and UMR 975, Université Paris 6, Hôpital Pitié‐Salpêtrière, Assistance Publique Hôpitaux de, Paris, France</affiliation><description>Correspondence: Unité des Pathologies du Sommeil, Hôpital Pitié‐Salpêtrière, 47‐83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-10-15</dateIssued><dateCaptured encoding="w3cdtf">2009-01-20</dateCaptured><dateValid encoding="w3cdtf">2009-07-05</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">42</extent><extent unit="words">5738</extent></physicalDescription><abstract lang="en">Parkin gene mutations cause a juvenile parkinsonism. Patients with these mutations may commonly exhibit REM sleep behaviour disorders, but other sleep problems (insomnia, sleepiness, restless legs syndrome) have not been studied. The aim of this study was to evaluate the sleep‐wake phenotype in patients with two parkin mutations, compared with patients with idiopathic Parkinson's disease (iPD). Sleep interview and overnight video‐polysomnography, followed by multiple sleep latency tests, were assessed in 11 consecutive patients with two parkin mutations (aged 35–60 years, from seven families) and 11 sex‐matched patients with iPD (aged 51–65 years). Sleep complaints in the parkin group included insomnia (73% patients versus 45% in the iPD group), restless legs syndrome (45%, versus none in the iPD group, P = 0.04), and daytime sleepiness (45%, versus 54% in the iPD group). Of the parkin patients, 45% had REM sleep without atonia, but only 9% had a definite REM sleep behavior disorder. All sleep measures were similar in the parkin and iPD groups. Two parkin siblings had a central hypersomnia, characterized by mean daytime sleep latencies of 3 min, no sleep onset REM periods, and normal nighttime sleep. Although the patients with two parkin mutations were young, their sleep phenotype paralleled the clinical and polygraphic sleep recording abnormalities reported in iPD, except that restless legs syndrome was more prevalent and secondary narcolepsy was absent. © 2007 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: All authors report no financial disclosure related to the research covered in the article. This was not an industry‐supported study.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>hypersomnia</topic><topic>restless legs syndrome</topic><topic>inborn genetic diseases</topic><topic>REM sleep behavior disorder</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Information Table E1. - Supporting Information Table E2. - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>13</number></detail><extent unit="pages"><start>1970</start><end>1976</end><total>7</total></extent></part></relatedItem><identifier type="istex">3AEDA0D9D64673FD2CEBE7DA12590A03F11454B6</identifier><identifier type="DOI">10.1002/mds.22711</identifier><identifier type="ArticleID">MDS22711</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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